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pentobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers may enhance the metabolism of ifosfamide to its Lively alkylating metabolites.We report a scenario of survival adhering to deliberate self-poisoning having a perhaps lethal dose of pentobarbital. In overdose,